This advanced textbook, , edited by Edda Klipp, is tailored for introductory courses in the field of Systems Biology. Suitable for biologists as well as engineers and computer scientists, it offers an accessible introduction to the subject matter. The book includes student-friendly reading lists and a companion website with a short exam prep version of the text and educational modeling programs. Each chapter features numerous worked examples and study questions designed to aid understanding. This second edition has been updated to include a section on medical systems biology, enhancing its relevance for a broader range of students and professionals.