Sample Size Calculations in Clinical Research (Chapman & Hall/CRC Biostatistics Series) offers a comprehensive guide to the statistical procedures essential for determining appropriate sample sizes during various phases of clinical research and development. Authored by Shein-Chung Chow, the third edition provides a strong organizational framework with carefully defined formulae, making it an invaluable resource for researchers designing studies. The book covers a wide range of topics including one-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes, with detailed calculations for testing equality, non-inferiority, and equivalence. Additionally, it delves into less familiar but crucial areas, ensuring a thorough understanding of sample size calculation methodologies in clinical research.

Praise from the academic community highlights the book’s utility: “… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study.” – Biometrics; and “This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered …” – Journal of the Royal Statistical Society. The third edition includes a balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation.

With 510 pages, this edition is a comprehensive resource for anyone involved in clinical research, ensuring that researchers are equipped with the knowledge to design studies effectively and efficiently.

Publication Date: September 30, 2020
Edition: 3rd
Language: English
Dimensions: 7.01 x 1.16 x 10 inches
ISBN-10: 367657767
ISBN-13: 978-0367657765

Read more to explore the detailed and practical guidance offered in this invaluable resource.