Principles of Computational Cell Biology: From Protein Complexes to Cellular Networks delves into the core concepts and applications of computational methods in understanding cellular processes. Authored by Volkhard Helms, this second edition is designed for biology students as well as those specializing in bioinformatics within mathematics and informatics. With a blend of biological insights and mathematical rigor, the book provides an accessible yet comprehensive exploration of the field. Approximately 50% of the content has been refreshed or added, focusing on advanced topics such as statistical methods, protein-DNA interactions, epigenetic modifications, and microRNAs. This edition ensures that readers gain a deep understanding of computational cell biology, making it indispensable for students and researchers alike.