Greene’s Protective Groups in Organic Synthesis is an indispensable reference for any practicing synthetic organic or medicinal chemist. This fifth edition continues the tradition of Greene’s, offering comprehensive coverage that provides the most relevant and useful examples to illustrate each methodology. The book presents valuable material on the application of protective groups in organic chemistry that is not easily found through casual searching. It helps chemists plan, investigate, and carry out organic syntheses in an efficient manner.

This edition adds over 2800 new references to update since the publication of the last edition, ensuring that it remains a cutting-edge resource. Reviews of the prior edition praised it as “an essential bible for the library or personal bookshelf of chemists performing complex synthesis.” It is also described as “the most up-to-date compilation available” and recommended as an integral part of all institutional libraries, with individuals highly encouraged to maintain their own copy.

The book covers 1408 pages, making it a thorough guide to the techniques for the formation and cleavage of protective groups. With its extensive references and practical examples, Greene’s Protective Groups in Organic Synthesis is an invaluable tool for anyone involved in organic synthesis or medicinal chemistry.