This textbook, Computational Biology: A Hypertextbook, authored by Scott T. Kelley, delves into the fundamental concepts and practical applications of bioinformatics—using computational methods to explore biological systems. The first edition, published by ASM Press on January 1, 2018, with ISBN-13 978-1683673033, is a comprehensive guide covering principles such as the analysis of DNA, RNA, and proteins, utilizing databases like NCBI and UniProt. It introduces readers to techniques including BLAST, sequence alignments, structural predictions, and phylogenetic tree creation.

Beyond its core content, the book offers a primer for beginners interested in computer programming within bioinformatics. Ideal as both a self-study resource and a course textbook focused on computational methods in biology or bioinformatics, this text also serves as a supplementary material for broader biological courses that incorporate relevant topics. The interactive online components enhance learning by gamifying problem-solving processes, allowing readers to tackle randomly generated challenges at their own pace, thereby building confidence and gaining practical experience.

These digital resources ensure the information remains current in an ever-evolving field of bioinformatics web-based programs, making Computational Biology: A Hypertextbook a valuable tool for students and professionals alike seeking to master computational approaches in biological research.